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isolated human pancreatic islets  (Prodo Labs)

 
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    Prodo Labs isolated human pancreatic islets
    Isolated Human Pancreatic Islets, supplied by Prodo Labs, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/isolated human pancreatic islets/product/Prodo Labs
    Average 90 stars, based on 1 article reviews
    isolated human pancreatic islets - by Bioz Stars, 2026-05
    90/100 stars

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    A Expression of OPRD1 , OPRK1 , and OPRM1 in human pancreatic islets ( n = 11) , , and expression of Oprd1 , Oprk1 , and Oprm1 in mouse pancreatic islets ( n = 14) , , assessed via RNA-seq. Data are mean ± SEM of TPM. B Expression of OPRD1 , OPRK1 , and OPRM1 was assessed in human purified pancreatic beta cells ( n = 11) and beta-cell depleted islet preparations (i.e., non-beta cells; n = 5) . Data are mean ± SEM of RPKM. C OPRD1 expression in human islets under different conditions and in type 2 diabetes. Brefeldin A (0.1 μg/mL; orange) vs control (green), 24 hours treatment ( n = 4); a combination of palmitate (0.5 mM) and high glucose (22.2 mM) (orange) vs control (green), 48 hours treatment ( n = 3); high glucose (22.2 mM; orange) vs control (green), 48 hours treatment ( n = 4); palmitate (0.5 mM; orange) vs control (green), 48 hours treatment ( n = 5); donors with type 2 diabetes ( n = 47; orange) vs non-diabetic controls ( n = 228; green). Data are box plots (showing the minimum, the median, the maximum, as well as all data). Adjusted P -values are shown relative to control and were calculated according to DESeq2 (v1.28.1; two-sided). ns not significant, RPKM reads per kilobase million, TPM transcripts per million.

    Journal: Nature Communications

    Article Title: Functional genetics reveals the contribution of delta opioid receptor to type 2 diabetes and beta-cell function

    doi: 10.1038/s41467-024-51004-6

    Figure Lengend Snippet: A Expression of OPRD1 , OPRK1 , and OPRM1 in human pancreatic islets ( n = 11) , , and expression of Oprd1 , Oprk1 , and Oprm1 in mouse pancreatic islets ( n = 14) , , assessed via RNA-seq. Data are mean ± SEM of TPM. B Expression of OPRD1 , OPRK1 , and OPRM1 was assessed in human purified pancreatic beta cells ( n = 11) and beta-cell depleted islet preparations (i.e., non-beta cells; n = 5) . Data are mean ± SEM of RPKM. C OPRD1 expression in human islets under different conditions and in type 2 diabetes. Brefeldin A (0.1 μg/mL; orange) vs control (green), 24 hours treatment ( n = 4); a combination of palmitate (0.5 mM) and high glucose (22.2 mM) (orange) vs control (green), 48 hours treatment ( n = 3); high glucose (22.2 mM; orange) vs control (green), 48 hours treatment ( n = 4); palmitate (0.5 mM; orange) vs control (green), 48 hours treatment ( n = 5); donors with type 2 diabetes ( n = 47; orange) vs non-diabetic controls ( n = 228; green). Data are box plots (showing the minimum, the median, the maximum, as well as all data). Adjusted P -values are shown relative to control and were calculated according to DESeq2 (v1.28.1; two-sided). ns not significant, RPKM reads per kilobase million, TPM transcripts per million.

    Article Snippet: Insulin secretion assays were performed on single isolated human pancreatic islets purchased from InSphero (Schlieren, Switzerland) as described by the manufacturer, from four donors.

    Techniques: Expressing, RNA Sequencing, Purification, Control